Partners in Crime

Dev Cell. 2017 Jun 19;41(6):573-574. doi: 10.1016/j.devcel.2017.06.002.

Abstract

Caspases have apoptotic and non-apoptotic functions, both of which depend on their abilities to cleave proteins at specific sites. What distinguishes apoptotic from non-apoptotic substrates has so far been unclear. In this issue of Developmental Cell, Weaver et al. (2017) now provide an answer to this crucial question.

Publication types

  • Review
  • Comment

MeSH terms

  • Animals
  • Apoptosis / physiology*
  • Caenorhabditis elegans Proteins / metabolism*
  • Caspases / metabolism*
  • Humans
  • RNA-Binding Proteins / genetics
  • RNA-Binding Proteins / metabolism
  • Signal Transduction / physiology
  • Ubiquitin-Protein Ligases / genetics
  • Ubiquitin-Protein Ligases / metabolism

Substances

  • Caenorhabditis elegans Proteins
  • Lin28A protein, human
  • RNA-Binding Proteins
  • UBR1 protein, human
  • Ubiquitin-Protein Ligases
  • Caspases
  • ced-3 protein, C elegans