Evaluation of Continuous Negative External Pressure (cNEP) for the Treatment of Obstructive Sleep Apnea: A Pilot Study

J Clin Sleep Med. 2017 Aug 15;13(8):1009-1012. doi: 10.5664/jcsm.6710.


Study objectives: To determine if the application of continuous negative external pressure (cNEP) is effective and safe in individuals with obstructive sleep apnea (OSA) during an overnight in-laboratory sleep study.

Methods: A prospective, open-label pilot study in subjects with documented OSA recruited from the patient population at one sleep clinic. The intervention was application and titration of cNEP during overnight polysomnography.

Results: Of the 15 subjects studied (mean apnea-hypopnea index [AHI] at baseline, 43.9 events/h), 13 (87%) were responders to cNEP: 9 had an excellent response (AHI < 5 events/h) and 4 had a partial response (AHI < 50% baseline and < 15 events/h). Three minor, self-limited adverse events occurred, which appeared related to contact pressure of the cNEP device on the skin.

Conclusions: In this pilot study, cNEP appears to be safe and effective during short-term use in subjects with OSA. Further studies are warranted.

Keywords: investigational therapies; medical device; negative pressure therapy; obstructive sleep apnea.

Publication types

  • Clinical Trial

MeSH terms

  • Adult
  • Aged
  • Female
  • Humans
  • Male
  • Middle Aged
  • Pilot Projects
  • Polysomnography
  • Prospective Studies
  • Respiration, Artificial / instrumentation
  • Respiration, Artificial / methods*
  • Sleep Apnea, Obstructive / therapy*