Treatment of a Focal Articular Cartilage Defect of the Talus with Polymer-Based Autologous Chondrocyte Implantation: A 12-Year Follow-Up Period

J Foot Ankle Surg. Jul-Aug 2017;56(4):862-864. doi: 10.1053/j.jfas.2017.03.001.

Abstract

Autologous chondrocyte implantation (ACI) is a first-line treatment option for large articular cartilage defects. Although well-established for cartilage defects in the knee, studies of the long-term outcomes of matrix-assisted ACI to treat cartilage defects in the ankle are rare. In the present report, we describe for the first time the long-term clinical and radiologic results 12 years after polymer-based matrix-assisted ACI treat a full-thickness talar cartilage defect in a 25-year-old male patient. The clinical outcome was assessed using the visual analog scale and Freiburg ankle score, magnetic resonance imaging evaluation using the Henderson-Kreuz scoring system and T2 mapping. Clinical assessment revealed improved visual analog scale and Freiburg ankle scores. The radiologic analysis and T2 relaxation time values indicated the formation of hyaline-like repair tissue. Polymer-based autologous chondrocytes has been shown to be a safe and clinically effective long-term treatment of articular cartilage defects in the talus.

Keywords: ankle; articular cartilage; autologous chondrocyte implantation; long-term follow-up; scaffold.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Biocompatible Materials
  • Cartilage Diseases / surgery*
  • Cartilage, Articular / injuries
  • Cartilage, Articular / surgery*
  • Chondrocytes / transplantation*
  • Follow-Up Studies
  • Humans
  • Male
  • Polymers
  • Talus / injuries
  • Talus / surgery*
  • Transplantation, Autologous

Substances

  • Biocompatible Materials
  • Polymers