T Cells From Patients With Parkinson's Disease Recognize α-synuclein Peptides

Nature. 2017 Jun 29;546(7660):656-661. doi: 10.1038/nature22815. Epub 2017 Jun 21.

Abstract

Genetic studies have shown the association of Parkinson's disease with alleles of the major histocompatibility complex. Here we show that a defined set of peptides that are derived from α-synuclein, a protein aggregated in Parkinson's disease, act as antigenic epitopes displayed by these alleles and drive helper and cytotoxic T cell responses in patients with Parkinson's disease. These responses may explain the association of Parkinson's disease with specific major histocompatibility complex alleles.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Alleles
  • Amino Acid Sequence
  • Autoimmunity
  • Epitopes, T-Lymphocyte / immunology
  • Female
  • HLA Antigens / genetics
  • HLA Antigens / immunology
  • Humans
  • Male
  • Middle Aged
  • Parkinson Disease / genetics
  • Parkinson Disease / immunology*
  • Parkinson Disease / pathology
  • Peptide Fragments / chemistry
  • Peptide Fragments / immunology
  • T-Lymphocytes / immunology*
  • T-Lymphocytes / pathology
  • T-Lymphocytes, Cytotoxic / immunology
  • T-Lymphocytes, Cytotoxic / pathology
  • T-Lymphocytes, Helper-Inducer / immunology
  • T-Lymphocytes, Helper-Inducer / pathology
  • alpha-Synuclein / chemistry
  • alpha-Synuclein / immunology*

Substances

  • Epitopes, T-Lymphocyte
  • HLA Antigens
  • Peptide Fragments
  • alpha-Synuclein