The present case report described a 61-year-old female patient who was diagnosed as Meige syndrome with double eyelid spasm, anxiety and insomnia. After she was treated with psychoactive drugs, it was found that clonazepam tablets in the benzodiazepine class and dopamine antagonist olanzapine tablets aggravated double eyelid spasm; while eszopiclone tablets as a specificity γ-aminobutyric acid receptor binding drug alleviated this condition. The present case suggests that psychoactive drugs have both positive and negative effects on treating Meige syndrome. As for the patients who also have emotion disorder, their conditions should be observed carefully when choosing which psychoactive drug to use. The specificity γ-aminobutyric acid receptor binding drugs should be the prime choice, such as eszopiclone.
本病例报告描述了一女性患者，61 岁，双眼睑 痉挛，诊断美格综合征(Meige syndrome)，伴焦虑失 眠症状，使用精神药物治疗时发现，苯二氮卓类药物 硝西泮片、多巴胺拮抗剂奥氮平片加重眼睑痉挛，特 异性γ- 氨基丁酸受体结合药物右佐匹克隆片则减轻眼 睑痉挛。本病例提示精神药物对美格综合征的影响存 在正面与负面的差异，对伴发情绪障碍的患者，在选 用精神药物治疗时应仔细观察评估病情，首选特异性γ- 氨基丁酸受体结合的药物，如右佐匹克隆。.
Keywords: Meige syndrome; clonazepam; eszopiclone; psychoactive drug.