Hypokalemia from beta 2-receptor stimulation by circulating epinephrine

Am J Cardiol. 1985 Aug 30;56(6):3D-9D. doi: 10.1016/0002-9149(85)91107-5.

Abstract

Beta 2-receptor stimulation is required for catecholamine-induced hypokalemia to occur. This hypokalemia is not mediated by insulin, renin or aldosterone. Catecholamine-induced hypokalemia can be prevented by selective beta 2 blockade, which does not abolish the inotropic effect of epinephrine.

MeSH terms

  • Adrenergic beta-Antagonists / pharmacology
  • Adrenergic beta-Antagonists / physiology
  • Digoxin / pharmacology
  • Dose-Response Relationship, Drug
  • Epinephrine / blood
  • Epinephrine / pharmacology
  • Epinephrine / physiology*
  • Heart Rate / drug effects
  • Humans
  • Hypokalemia / chemically induced
  • Hypokalemia / physiopathology*
  • Insulin / blood
  • Isoproterenol / pharmacology
  • Myocardial Infarction / blood
  • Physical Exertion
  • Potassium / blood*
  • Propanolamines / pharmacology
  • Time Factors

Substances

  • Adrenergic beta-Antagonists
  • Insulin
  • Propanolamines
  • ICI 118551
  • Digoxin
  • Isoproterenol
  • Potassium
  • Epinephrine