Live or Die? Depends on Who You Are

Neuron. 2017 Jun 21;94(6):1043-1046. doi: 10.1016/j.neuron.2017.06.016.


In this issue of Neuron, Welsbie et al. (2017) and Norsworthy et al. (2017) implicate the transcription factor Sox11 as a key player after optic nerve injury-in DLK signaling of RGC cell death, and in RGC regeneration and survival but only in certain RGCs.

Keywords: DLK; PTEN; axon regeneration; cell death; ceramide; retinal ganglion cell.

MeSH terms

  • Axons*
  • Cell Death
  • Cell Survival
  • Humans
  • Nerve Regeneration
  • Optic Nerve
  • Optic Nerve Injuries
  • Retinal Ganglion Cells*
  • Signal Transduction