Ring-substituted beta-methoxyphenethylamines: a new class of psychotomimetic agents active in man

J Pharm Pharmacol. 1985 Aug;37(8):575-7. doi: 10.1111/j.2042-7158.1985.tb03072.x.

Abstract

Four members of a new class of psychotomimetic agents have been synthesized and evaluated in man. These compounds, which incorporate a beta-methoxy group onto a beta-phenethylamine sidechain, are the first reported psychotomimetics which are structural analogues of the neurotransmitter noradrenaline. These substances are more potent than the corresponding phenethylamines (lacking a beta-methoxy group) but less potent than the correspondingly substituted amphetamine derivatives.

MeSH terms

  • Adult
  • Aged
  • Chemical Phenomena
  • Chemistry
  • Female
  • Hallucinogens / chemical synthesis*
  • Humans
  • Male
  • Mescaline / pharmacology
  • Middle Aged
  • Norepinephrine / analogs & derivatives
  • Tyramine / analogs & derivatives*
  • Tyramine / chemical synthesis

Substances

  • Hallucinogens
  • Mescaline
  • O-methyltyramine
  • Norepinephrine
  • Tyramine