ACSF3 and Mal(onate)-Adapted Mitochondria

Cell Chem Biol. 2017 Jun 22;24(6):649-650. doi: 10.1016/j.chembiol.2017.06.004.


In this issue of Cell Chemical Biology, Bowman and colleagues show that the mitochondrial enzyme ACSF3 generates malonyl-CoA from malonate, in turn regulating metabolic flux and mitochondrial protein malonylation (Bowman et al., 2017). The study reveals a mechanism to generate mitochondrial malonyl-CoA and how this molecule impacts mitochondrial biology.

MeSH terms

  • Animals
  • Coenzyme A Ligases / metabolism*
  • Humans
  • Malonates / metabolism*
  • Malonyl Coenzyme A / metabolism
  • Mice
  • Mitochondria / metabolism*
  • Mitochondrial Proteins / metabolism
  • Protein Processing, Post-Translational


  • Malonates
  • Mitochondrial Proteins
  • Malonyl Coenzyme A
  • malonic acid
  • ACSF3 protein, human
  • Coenzyme A Ligases