Olfactory identification deficit predicts white matter tract impairment in Alzheimer's disease

Psychiatry Res Neuroimaging. 2017 Aug 30;266:90-95. doi: 10.1016/j.pscychresns.2017.06.004. Epub 2017 Jun 9.

Abstract

Olfactory identification deficit (OID) has been associated with both aging and Alzheimer's disease (AD). In the context of an amnestic disorders, OID predicts conversion to AD. Neuroanatomical correlates could increase specificity and sensitivity and elucidate the mechanistic differences between OID in AD and aging. Cross-sectional analysis of white matter microstructural changes was performed using diffusion tensor imaging (DTI) and tract-based-spatial-statistics in amnestic mild cognitive impairment (aMCI), AD and normal controls (NC) in 66 subjects (26 AD, 15 aMCI, 25 NC). DTI 3-Tesla MRI scans were analyzed and subject level means for fractional anisotropy (FA), mean diffusivity (MD), radial and axial diffusivity (λ1D and λ2,3D) were calculated. Linear regression models were applied using DTI markers as predictor and OID as outcome. OID was associated with increased λ1D in aMCI and increased MD, λ1D and λ2,3D in AD. Voxel-wise analyses revealed widespread differences in all markers in AD. There were significant differences in λ1D in aMCI, particularly in the olfactory tract. OID is correlated with microstructural white matter changes as early as in aMCI. This study may help elucidate the biological basis for olfactory impairment in Alzheimer's disease. Neuroanatomical correlates could help distinguish OID associated with AD and that associated with aging.

Keywords: Alzheimer's disease; Amnestic mild cognitive impairment; Diffusion tensor imaging; MRI; Olfactory; White Matter.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Alzheimer Disease* / complications
  • Alzheimer Disease* / diagnostic imaging
  • Alzheimer Disease* / pathology
  • Alzheimer Disease* / physiopathology
  • Cognitive Dysfunction* / complications
  • Cognitive Dysfunction* / diagnostic imaging
  • Cognitive Dysfunction* / pathology
  • Cognitive Dysfunction* / physiopathology
  • Cross-Sectional Studies
  • Diffusion Tensor Imaging / methods*
  • Female
  • Humans
  • Male
  • Olfaction Disorders* / diagnostic imaging
  • Olfaction Disorders* / etiology
  • Olfaction Disorders* / pathology
  • Olfaction Disorders* / physiopathology
  • White Matter / diagnostic imaging
  • White Matter / pathology*