Resveratrol Improved the Progression of Chronic Prostatitis via the Downregulation of c-kit/SCF by Activating Sirt1

J Agric Food Chem. 2017 Jul 19;65(28):5668-5673. doi: 10.1021/acs.jafc.7b01879. Epub 2017 Jul 5.

Abstract

The regulation mechanism of inflammation inducing prostate carcinogenesis remains largely unknown. Therefore, we investigated the role of the c-kit/SCF pathway, which has been associated with the control of prostate carcinogenesis, in chronic prostatitis (CP) rats and evaluated the anti-prostatitis effect of resveratrol. We performed hemolysin and eosin staining to evaluate the histopathological changes in prostates. Multiple approaches evaluated the expression levels of c-kit, stem cell factor (SCF), Sirt1, and carcinogenesis-associated proteins. The CP group exhibited severe diffuse chronic inflammation. Meanwhile, the prostate cells appeared atypia; the activity of c-kit/SCF was upregulated, and carcinogenesis-associated proteins are dysregulated significantly in CP rats. Resveratrol treatment significantly improved these factors by Sirt1 activation. In summary, CP could further cause prostate carcinogenesis, which may be associated with activated c-kit/SCF signaling. Resveratrol treatment could improve the progression of CP via the downregulation of c-kit/SCF by activating Sirt1.

Keywords: Sirt1; c-kit/SCF; carcinogenesis; chronic prostatitis; resveratrol.

MeSH terms

  • Animals
  • Disease Progression
  • Down-Regulation
  • Humans
  • Male
  • Prostatitis / drug therapy*
  • Prostatitis / genetics
  • Prostatitis / metabolism
  • Prostatitis / pathology
  • Proto-Oncogene Proteins c-kit / genetics*
  • Proto-Oncogene Proteins c-kit / metabolism
  • Rats
  • Rats, Sprague-Dawley
  • Resveratrol
  • Signal Transduction / drug effects
  • Sirtuin 1 / genetics
  • Sirtuin 1 / metabolism*
  • Stem Cell Factor / genetics*
  • Stem Cell Factor / metabolism
  • Stilbenes / administration & dosage*

Substances

  • Stem Cell Factor
  • Stilbenes
  • Proto-Oncogene Proteins c-kit
  • Sirt1 protein, rat
  • Sirtuin 1
  • Resveratrol