Pro- versus Anti-inflammatory Actions of HDLs in Innate Immunity

Cell Metab. 2017 Jul 5;26(1):2-3. doi: 10.1016/j.cmet.2017.04.007. Epub 2017 Jun 22.


High-density lipoproteins (HDLs) can inhibit inflammatory cytokine expression on innate immune cells, but sometimes they promote cytokine production as suggested in a recent article in Cell Metabolism by van der Vorst et al. (2017). Kopecky et al. point out that the origin, handling, and storage conditions of HDL preparations dictate their functional properties and can specifically affect immune cells to evoke a pro-inflammatory response.

Keywords: HDL quality; HDLs; immune cells; inflammatory properties; innate immunity.

Publication types

  • Letter

MeSH terms

  • Animals
  • Cytokines / immunology
  • Humans
  • Immunity, Cellular
  • Immunity, Innate*
  • Inflammation / immunology
  • Lipoproteins, HDL / immunology*
  • Macrophages / immunology


  • Cytokines
  • Lipoproteins, HDL