Somatostatin and water excretion in man: an intrarenal action

Clin Endocrinol (Oxf). 1985 Aug;23(2):169-74. doi: 10.1111/j.1365-2265.1985.tb00212.x.


Intravenous infusion of somatostatin in six water loaded normal human subjects produced a prompt reduction in urine flow accompanied by a rise in urine osmolality and a decrease in free water clearance. Plasma AVP levels did not change. Somatostatin would seem to exert an antidiuretic effect directly on the kidney.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Arginine Vasopressin / blood
  • Female
  • Humans
  • Kidney / drug effects*
  • Male
  • Osmolar Concentration
  • Somatostatin / pharmacology*
  • Urination / drug effects
  • Water / metabolism*


  • Water
  • Arginine Vasopressin
  • Somatostatin