Studies of contents of norepinephrine and 5-hydroxytryptamine in brain--I. Normal and cold exposure

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1985;82(1):155-8. doi: 10.1016/0742-8413(85)90223-3.


The levels of NE and 5-HT were determined in different brain regions of the field rat and the guinea-pig under normal conditions and following cold exposure at 10 degrees C. Under normal conditions NE was found to be mainly accumulated in the midbrain while 5-HT exhibited its highest value in the pons plus medulla of both animals. Cold exposure of the field rat caused a general increase in NE concentrations while a general decrease occurred in the brain regions of the guinea-pig. 5-HT mostly decreased in the two animals. These changes in the amine levels could be related directly to the animal's response to cold.

MeSH terms

  • Animals
  • Brain / metabolism*
  • Brain Mapping
  • Cold Temperature
  • Female
  • Guinea Pigs
  • Male
  • Muridae
  • Norepinephrine / metabolism*
  • Serotonin / metabolism*


  • Serotonin
  • Norepinephrine