The many postures of noncanonical Wnt signaling in development and diseases

doi:10.1016/j.biopha.2017.06.061

Review

. 2017 Sep:93:359-369.

doi: 10.1016/j.biopha.2017.06.061. Epub 2017 Jun 24.

The many postures of noncanonical Wnt signaling in development and diseases

Qian Xiao¹, Zhengxi Chen², Xiaozhuang Jin³, Runyi Mao⁴, Zhenqi Chen⁵

Affiliations

¹ Senior Research Scientist, Department of Pharmacology, School of Medicine, Yale University, New Haven, USA.
² PhD, Department of Orthodontics, Ninth People's Hospital, School of Stomatology, Shanghai Key Laboratory of Stomatology, Shanghai Jiao Tong University, Shanghai, China.
³ PhD, Faculty of Dentistry, The University of Hong Kong, Hong Kong.
⁴ MDS student, Department of Oral and Maxillofacial Surgery, Ninth People's Hospital, School of Stomatology, Shanghai Key Laboratory of Stomatology, Shanghai Jiao Tong University, Shanghai, China.
⁵ Professor, Department of Orthodontics, Ninth People's Hospital, School of Stomatology, Shanghai Key Laboratory of Stomatology, Shanghai Jiao Tong University, Shanghai, China.

PMID: 28651237
DOI: 10.1016/j.biopha.2017.06.061

Review

The many postures of noncanonical Wnt signaling in development and diseases

Qian Xiao et al. Biomed Pharmacother. 2017 Sep.

. 2017 Sep:93:359-369.

doi: 10.1016/j.biopha.2017.06.061. Epub 2017 Jun 24.

Authors

Qian Xiao¹, Zhengxi Chen², Xiaozhuang Jin³, Runyi Mao⁴, Zhenqi Chen⁵

Affiliations

¹ Senior Research Scientist, Department of Pharmacology, School of Medicine, Yale University, New Haven, USA.
² PhD, Department of Orthodontics, Ninth People's Hospital, School of Stomatology, Shanghai Key Laboratory of Stomatology, Shanghai Jiao Tong University, Shanghai, China.
³ PhD, Faculty of Dentistry, The University of Hong Kong, Hong Kong.
⁴ MDS student, Department of Oral and Maxillofacial Surgery, Ninth People's Hospital, School of Stomatology, Shanghai Key Laboratory of Stomatology, Shanghai Jiao Tong University, Shanghai, China.
⁵ Professor, Department of Orthodontics, Ninth People's Hospital, School of Stomatology, Shanghai Key Laboratory of Stomatology, Shanghai Jiao Tong University, Shanghai, China.

PMID: 28651237
DOI: 10.1016/j.biopha.2017.06.061

Abstract

Wnt signaling regulates many aspects of vertebrate development. Its dysregulation causes developmental defects and diseases including cancer. The signaling can be categorized in two pathways: canonical and noncanonical. Canonical pathway plays a key role in regulating proliferation and differentiation of cells whilst noncanonical Wnt signaling mainly controls cellular polarity and motility. During development, noncanonical Wnt signaling is required for tissue formation. Recent studies have shown that noncanonical Wnt signaling is involved in adult tissue development and cancer progression. In this review, we try to describe and discuss the mechanisms behind the biological effects of noncanonical Wnt signaling, diseases caused by its dysregulation, and implications in adult tissue development biology.

Keywords: Development; Disease; Noncanonical wnt signaling; Review.

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The many postures of noncanonical Wnt signaling in development and diseases

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The many postures of noncanonical Wnt signaling in development and diseases

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