Structure of the LPS O-chain from Fusobacterium nucleatum strain 12230

Evgeny Vinogradov; Frank St Michael; Andrew D Cox

doi:10.1016/j.carres.2017.06.007

Structure of the LPS O-chain from Fusobacterium nucleatum strain 12230

Carbohydr Res. 2017 Aug 7:448:115-117. doi: 10.1016/j.carres.2017.06.007. Epub 2017 Jun 16.

Authors

Evgeny Vinogradov¹, Frank St Michael², Andrew D Cox²

Affiliations

¹ Vaccine Program, Human Health Therapeutics Portfolio, National Research Council, Ottawa, ON, K1A 0R6, Canada. Electronic address: Evguenii.Vinogradov@nrc-cnrc.gc.ca.
² Vaccine Program, Human Health Therapeutics Portfolio, National Research Council, Ottawa, ON, K1A 0R6, Canada.

PMID: 28651243
DOI: 10.1016/j.carres.2017.06.007

Abstract

Fusobacterium nucleatum is an anaerobic bacterium found in the human mouth where it causes periodontitis. It was also found in colorectal cancer tissues and is linked with pregnancy complications, including pre-term and still births. Cell surface structures of the bacterium could be implicated in pathogenesis. Here we report the following structure of the lipopolysaccharide O-chain of F. nucleatum strain 12230: -6-α-d-Glc-4-β-d-GlcNHBu3NHBuA-3-β-d-QuiNAc4NABu- where ABu and HBu indicate (R)-3-aminobutanoyl and (R)-3-hydroxybutanoyl, respectively; all monosaccharides are in the pyranose form.

Keywords: Fusobacterium nucleatum; Lipopolysaccharide; NMR spectroscopy; Polysaccharide structure.

MeSH terms

Carbohydrate Sequence
Fusobacterium nucleatum / chemistry*
O Antigens / chemistry*

Substances

O Antigens