Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017;411:141-169.
doi: 10.1007/82_2017_11.

Ebola Virus Disease in Humans: Pathophysiology and Immunity

Affiliations
Free PMC article
Review

Ebola Virus Disease in Humans: Pathophysiology and Immunity

César Muñoz-Fontela et al. Curr Top Microbiol Immunol. .
Free PMC article

Abstract

Viruses of the Ebolavirus genus cause sporadic epidemics of severe and systemic febrile disease that are fueled by human-to-human transmission. Despite the notoriety of ebolaviruses, particularly Ebola virus (EBOV), as prominent viral hemorrhagic fever agents, and the international concern regarding Ebola virus disease (EVD) outbreaks, very little is known about the pathophysiology of EVD in humans and, in particular, about the human immune correlates of survival and immune memory. This lack of basic knowledge about physiological characteristics of EVD is probably attributable to the dearth of clinical and laboratory data gathered from past outbreaks. The unprecedented magnitude of the EVD epidemic that occurred in West Africa from 2013 to 2016 has allowed, for the first time, evaluation of clinical, epidemiological, and immunological parameters in a significant number of patients using state-of-the-art laboratory equipment. This review will summarize the data from the literature regarding human pathophysiologic and immunologic responses to filoviral infection.

Similar articles

  • Effectiveness of Ring Vaccination as Control Strategy for Ebola Virus Disease.
    Kucharski AJ, Eggo RM, Watson CH, Camacho A, Funk S, Edmunds WJ. Kucharski AJ, et al. Emerg Infect Dis. 2016 Jan;22(1):105-8. doi: 10.3201/eid2201.151410. Emerg Infect Dis. 2016. PMID: 26691346 Free PMC article.
  • Treatment of ebola virus disease.
    Kilgore PE, Grabenstein JD, Salim AM, Rybak M. Kilgore PE, et al. Pharmacotherapy. 2015 Jan;35(1):43-53. doi: 10.1002/phar.1545. Pharmacotherapy. 2015. PMID: 25630412 Review.
  • Immune barriers of Ebola virus infection.
    McElroy AK, Mühlberger E, Muñoz-Fontela C. McElroy AK, et al. Curr Opin Virol. 2018 Feb;28:152-160. doi: 10.1016/j.coviro.2018.01.010. Epub 2018 Feb 16. Curr Opin Virol. 2018. PMID: 29452995 Free PMC article. Review.
  • Delayed recognition of Ebola virus disease is associated with longer and larger outbreaks.
    Matson MJ, Chertow DS, Munster VJ. Matson MJ, et al. Emerg Microbes Infect. 2020 Feb 4;9(1):291-301. doi: 10.1080/22221751.2020.1722036. eCollection 2020. Emerg Microbes Infect. 2020. PMID: 32013784 Free PMC article.
  • An Outbreak of Ebola Virus Disease in the Lassa Fever Zone.
    Goba A, Khan SH, Fonnie M, Fullah M, Moigboi A, Kovoma A, Sinnah V, Yoko N, Rogers H, Safai S, Momoh M, Koroma V, Kamara FK, Konowu E, Yillah M, French I, Mustapha I, Kanneh F, Foday M, McCarthy H, Kallon T, Kallon M, Naiebu J, Sellu J, Jalloh AA, Gbakie M, Kanneh L, Massaly JL, Kargbo D, Kargbo B, Vandi M, Gbetuwa M, Gevao SM, Sandi JD, Jalloh SC, Grant DS, Blyden SO, Crozier I, Schieffelin JS, McLellan SL, Jacob ST, Boisen ML, Hartnett JN, Cross RW, Branco LM, Andersen KG, Yozwiak NL, Gire SK, Tariyal R, Park DJ, Haislip AM, Bishop CM, Melnik LI, Gallaher WR, Wimley WC, He J, Shaffer JG, Sullivan BM, Grillo S, Oman S, Garry CE, Edwards DR, McCormick SJ, Elliott DH, Rouelle JA, Kannadka CB, Reyna AA, Bradley BT, Yu H, Yenni RE, Hastie KM, Geisbert JB, Kulakosky PC, Wilson RB, Oldstone MB, Pitts KR, Henderson LA, Robinson JE, Geisbert TW, Saphire EO, Happi CT, Asogun DA, Sabeti PC, Garry RF; Viral Hemorrhagic Fever Consortium. Goba A, et al. J Infect Dis. 2016 Oct 15;214(suppl 3):S110-S121. doi: 10.1093/infdis/jiw239. Epub 2016 Jul 11. J Infect Dis. 2016. PMID: 27402779 Free PMC article.
See all similar articles

Cited by 7 articles

See all "Cited by" articles

References

    1. Adjemian J, Farnon EC, Tschioko F, Wamala JF, Byaruhanga E, Bwire GS, Kansiime E, Kagirita A, Ahimbisibwe S, Katunguka F, Jeffs B, Lutwama JJ, Downing R, Tappero JW, Formenty P, Amman B, Manning C, Towner J, Nichol ST, Rollin PE. Outbreak of Marburg hemorrhagic fever among miners in Kamwenge and Ibanda Districts, Uganda, 2007. J Infect Dis. 2011;204(Suppl 3):S796–799. doi: 10.1093/infdis/jir312. - DOI - PMC - PubMed
    1. Agnandji ST, Huttner A, Zinser ME, Njuguna P, Dahlke C, Fernandes JF, Yerly S, Dayer JA, Kraehling V, Kasonta R, Adegnika AA, Altfeld M, Auderset F, Bache EB, Biedenkopf N, Borregaard S, Brosnahan JS, Burrow R, Combescure C, Desmeules J, Eickmann M, Fehling SK, Finckh A, Goncalves AR, Grobusch MP, Hooper J, Jambrecina A, Kabwende AL, Kaya G, Kimani D, Lell B, Lemaitre B, Lohse AW, Massinga-Loembe M, Matthey A, Mordmuller B, Nolting A, Ogwang C, Ramharter M, Schmidt-Chanasit J, Schmiedel S, Silvera P, Stahl FR, Staines HM, Strecker T, Stubbe HC, Tsofa B, Zaki S, Fast P, Moorthy V, Kaiser L, Krishna S, Becker S, Kieny MP, Bejon P, Kremsner PG, Addo MM, Siegrist CA. Phase 1 Trials of rVSV Ebola Vaccine in Africa and Europe. N Engl J Med. 2016;374(17):1647–1660. doi: 10.1056/NEJMoa1502924. - DOI - PMC - PubMed
    1. Alvarez CP, Lasala F, Carrillo J, Muniz O, Corbi AL, Delgado R. C-type lectins DC-SIGN and L-SIGN mediate cellular entry by Ebola virus in cis and in trans. J Virol. 2002;76(13):6841–6844. doi: 10.1128/JVI.76.13.6841-6844.2002. - DOI - PMC - PubMed
    1. Amman BR, Carroll SA, Reed ZD, Sealy TK, Balinandi S, Swanepoel R, Kemp A, Erickson BR, Comer JA, Campbell S, Cannon DL, Khristova ML, Atimnedi P, Paddock CD, Crockett RJ, Flietstra TD, Warfield KL, Unfer R, Katongole-Mbidde E, Downing R, Tappero JW, Zaki SR, Rollin PE, Ksiazek TG, Nichol ST, Towner JS. Seasonal pulses of Marburg virus circulation in juvenile Rousettus aegyptiacus bats coincide with periods of increased risk of human infection. PLoS Pathog. 2012;8(10):e1002877. doi: 10.1371/journal.ppat.1002877. - DOI - PMC - PubMed
    1. Appay V, Dunbar PR, Callan M, Klenerman P, Gillespie GM, Papagno L, Ogg GS, King A, Lechner F, Spina CA, Little S, Havlir DV, Richman DD, Gruener N, Pape G, Waters A, Easterbrook P, Salio M, Cerundolo V, McMichael AJ, Rowland-Jones SL. Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections. Nat Med. 2002;8(4):379–385. doi: 10.1038/nm0402-379. - DOI - PubMed

MeSH terms

Feedback