Clinical significance of fascin-1 and laminin-5 in non-small cell lung cancer

Genet Mol Res. 2017 Jun 20;16(2). doi: 10.4238/gmr16029617.

Abstract

Lung cancer is the leading cause of cancer death in men and the second leading cause of cancer death in women worldwide. Fascin-1 and laminin-5 were associated with the invasiveness and prognoses of several cancers. The expression and the serum levels of fascin-1 and laminin-5 in patients with non-small cell lung cancer (NSCLC) were analyzed in this study. The expression of fascin-1 and laminin-5 were examined in 378 patients and their serum level was measured in 154 patients. The health of all patients was followed post-surgery. The expression of fascin-1 (P = 0.000) and lanminin-5 (P = 0.001) and the serum levels of fascin-1 (P = 0.015) and laminin-5 (P = 0.046) were related to the relapse of patients with NSCLC. Both serum levels and expression of fascin-1 and laminin-5 can be used to effectively evaluate the prognoses of patients with NSCLC.

MeSH terms

  • Carcinoma, Non-Small-Cell Lung / blood
  • Carcinoma, Non-Small-Cell Lung / genetics
  • Carcinoma, Non-Small-Cell Lung / metabolism*
  • Carcinoma, Non-Small-Cell Lung / pathology
  • Carrier Proteins / blood
  • Carrier Proteins / genetics*
  • Cell Adhesion Molecules / blood
  • Cell Adhesion Molecules / genetics*
  • Female
  • Gene Expression Regulation, Neoplastic*
  • Humans
  • Lung Neoplasms / blood
  • Lung Neoplasms / genetics
  • Lung Neoplasms / metabolism*
  • Lung Neoplasms / pathology
  • Male
  • Microfilament Proteins / blood
  • Microfilament Proteins / genetics*
  • Neoplasm Recurrence, Local

Substances

  • Carrier Proteins
  • Cell Adhesion Molecules
  • FSCN1 protein, human
  • Microfilament Proteins
  • kalinin