Successful treatment for thrombotic thrombocytopenic purpura complicated with myeloperoxidase anti-neutrophil cytoplasmic autoantibody-associated vasculitis

Yoko Yamauchi; Katsuyuki Nagatoya; Ayako Okuno; Naohiko Fujii; Toru Inoue

doi:10.1093/ndtplus/sfq013

Successful treatment for thrombotic thrombocytopenic purpura complicated with myeloperoxidase anti-neutrophil cytoplasmic autoantibody-associated vasculitis

NDT Plus. 2010 Jun;3(3):279-281. doi: 10.1093/ndtplus/sfq013. Epub 2010 Feb 28.

Authors

Yoko Yamauchi^{1

2}, Katsuyuki Nagatoya², Ayako Okuno¹, Naohiko Fujii¹, Toru Inoue²

Affiliations

¹ Department of Nephrology, Hyogo Prefectural Nishinomiya Hospital, Hyogo, Japan.
² Department of Nephrology, Osaka Medical College, Osaka, Japan.

Abstract

Thrombotic thrombocytopenic purpura (TTP) complicated with myeloperoxidase anti-neutrophil cytoplasmic autoantibody (MPO-ANCA)-associated vasculitis is rare and generally has a serious prognosis. We report a case wherein TTP was successfully treated with repeated plasma exchange (PE) and MPO-ANCA-associated vasculitis with corticosteroids. The renal function consequently improved such that haemodialysis could be discontinued and the patient was discharged without any significant complications.

Keywords: myeloperoxidase anti-neutrophil cytoplasmic autoantibody (MPO-ANCA)-associated vasculitis; plasma exchange (PE); thrombotic thrombocytopenic purpura (TTP).

Publication types

Case Reports