Renal sympathetic nerve responses to stimulation, inhibition and destruction of the ventrolateral medulla in the rabbit

Neurosci Lett. 1985 Sep 16;60(1):51-5. doi: 10.1016/0304-3940(85)90380-5.

Abstract

The role of the sympathetic nervous system in the cardiovascular responses to lesions of the caudal ventrolateral medulla of the rabbit was investigated by measurement of renal sympathetic nerve activity. In addition, the effect of chemical stimulation and inhibition on renal sympathetic nerve activity was assessed. The results show that lesions or chemical inhibition of the caudal ventrolateral medulla result in an increase in sympathetic nerve activity and blood pressure, whilst excitation results in a decrease in blood pressure and nerve activity. These findings contrast with chemical stimulation or inhibition of the rostral ventrolateral medulla in the region of the C1 cells where stimulation results in a rise in blood pressure and renal nerve activity, and inhibition, a fall in blood pressure and nerve activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Autonomic Fibers, Postganglionic / physiology
  • Blood Pressure
  • Female
  • Glutamates / pharmacology
  • Glutamic Acid
  • Heart Rate
  • Kidney / innervation*
  • Male
  • Medulla Oblongata / drug effects
  • Medulla Oblongata / physiology*
  • Neural Inhibition
  • Rabbits
  • Sympathetic Nervous System / physiology*
  • gamma-Aminobutyric Acid / pharmacology

Substances

  • Glutamates
  • Glutamic Acid
  • gamma-Aminobutyric Acid