mTORC1 Controls Synthesis of Its Activator GTP

Cell Rep. 2017 Jun 27;19(13):2643-2644. doi: 10.1016/j.celrep.2017.06.032.


In this issue of Cell Reports, Emmanuel et al. (2017) report that mTORC1 activity is regulated by purine availability. This increases the number of mTORC1 regulators to include metabolites whose synthesis mTORC1 controls.

Publication types

  • Review

MeSH terms

  • Humans
  • Mechanistic Target of Rapamycin Complex 1 / metabolism*
  • Monomeric GTP-Binding Proteins / metabolism*
  • TOR Serine-Threonine Kinases / metabolism*


  • Mechanistic Target of Rapamycin Complex 1
  • TOR Serine-Threonine Kinases
  • Monomeric GTP-Binding Proteins