Sensitization to 10 mites in a tropic area. Der p and Der f are important risk factor for sensitization to other mites from Pyroglyphidae, Acaridae, Chortoglyphidae, and Glyciphagidae families

Rev Alerg Mex. Apr-Jun 2017;64(2):153-162. doi: 10.29262/ram.v64i2.243.

Abstract

Background: Much is known about the frequency of sensitization to Blomia tropicalis, Dermatophagoides pteronyssinus and Dermatophagoides farinae, although less is known about sensitization to other species and their possible interactions.

Objective: In patients with allergic manifestations, to evaluate the frequency of sensitization to 10 species of mites in a tropical area and their possible interactions.

Methods: Cross-sectional study. Sensitization was evaluated by skin tests. A generalized linear Poisson regression model with robust variance was used. Based on the sensitization probability reasons and social networking analysis, explorations of relationship for 10 mites were performed.

Results: 147 patients were included. The highest sensitization was found to mites' family Pyroglyphidae (> 70 %) and less frequently was the Glycyphagidae family (< 50 %). Sensitization to any mites significantly increased the likelihood of sensitization to others. Sensitization to Der f or Der p increased, more than 20 times the likelihood of sensitization to other mites of the Pyroglyphidae family and more than 10 times to mites from other families. Sensitization to mites from Glycyphagidae, Chortoglyphidae or Acaridae family also increased the risk of sensitization to other mites but less than 5 times.

Conclusion: Sensitization to mites is frequent in tropical area. Pyroglyphidae sensitization is the main risk factor for polysensitization with other mites from Glycyphagidae, Chortoglyphidae or Acaridae. These results must be considered at diagnosis and treatment of allergy diseases.

Keywords: Allergen; Allergy; Atopy; Mites; Network analysis; Sensitization.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Animals
  • Antigens, Dermatophagoides / adverse effects
  • Antigens, Dermatophagoides / immunology
  • Arthropod Proteins / adverse effects
  • Arthropod Proteins / immunology
  • Child
  • Child, Preschool
  • Colombia
  • Cross-Sectional Studies
  • Cysteine Endopeptidases / adverse effects
  • Cysteine Endopeptidases / immunology
  • Female
  • Humans
  • Hypersensitivity, Immediate / epidemiology
  • Hypersensitivity, Immediate / etiology*
  • Male
  • Middle Aged
  • Mites / classification
  • Mites / immunology*
  • Risk Factors
  • Serine Endopeptidases / adverse effects
  • Serine Endopeptidases / immunology
  • Skin Tests
  • Species Specificity
  • Tropical Climate
  • Young Adult

Substances

  • Antigens, Dermatophagoides
  • Arthropod Proteins
  • Dermatophagoides pteronyssinus antigen p 3
  • Serine Endopeptidases
  • Cysteine Endopeptidases
  • Dermatophagoides farinae antigen f 1