Strengthening brittle bones

Sci Transl Med. 2017 Jun 28;9(396):eaan6730. doi: 10.1126/scitranslmed.aan6730.

Abstract

Decreased WNT1 signaling weakens bones but is partially reversed by blocking the WNT1 inhibitory regulator sclerostin.

Publication types

  • Comment

MeSH terms

  • Bone and Bones
  • Homeostasis
  • Humans
  • Osteocytes*
  • Osteogenesis Imperfecta*
  • Wnt1 Protein

Substances

  • WNT1 protein, human
  • Wnt1 Protein