Somatostatin-like immunoreactive cells of an open type have been identified in the digestive tract of the cartilaginous fish Scyliorhinus stellaris (L.) by the use of immunocytochemical techniques. In the stomach these cells are numerous both in the corpus (neck zone and tubular glands) and in the pyloric portion (crypts). In the spiral valve, somatostatin-like cells are rare, situated in the intestinal epithelium and without any particular localization. Using semithin serial sections, somatostatin-like cells are found to be Davenport-negative and weakly positive towards the Grimelius silver reaction, and using the semithin and ultrathin technique have been identified at the ultrastructural level; their secretory granules appear electron dense, round or slightly polygonal, and with a limiting membrane tightly adherent to the core. The mean diameter varies from 250-300 nm.