Histochemical demonstration of peptidases in the human kidney

Histochemistry. 1985;83(4):337-41. doi: 10.1007/BF00684380.


The localization of several peptidases in the human kidney was investigated histochemically. The membrane-bound peptidases, aminopeptidase A (APA), aminopeptidase M, gamma-glutamyltransferase (gamma-GT) and dipeptidylpeptidase IV, were mainly demonstrable in the brush border of the proximal tubule. In addition, APA was found in the glomeruli, while gamma-GT was found in the basal labyrinth of the proximal tubule. The lysosomal peptidases, dipeptidylpeptidase I and cathepsin B, were most strongly concentrated in the different-sized lysosomes of the proximal tubule, but they were also found in the small lysosomes of the distal tubule. Dipeptidylpeptidase II showed only a weak reaction in lysosomes of the proximal tubule. It is concluded that, in comparison with other previously studied species, the human kidney has a well-developed equipment with membrane-bound and lysosomal peptidases.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aminopeptidases / analysis*
  • Cathepsin B
  • Cathepsin C
  • Cathepsins / analysis
  • Cell Membrane / enzymology
  • Cell Membrane / ultrastructure
  • Dipeptidyl Peptidase 4
  • Dipeptidyl-Peptidases and Tripeptidyl-Peptidases / analysis*
  • Female
  • Histocytochemistry
  • Humans
  • Kidney / enzymology*
  • Kidney / ultrastructure
  • Male
  • Microscopy, Electron
  • Microvilli / enzymology
  • Microvilli / ultrastructure
  • Middle Aged
  • gamma-Glutamyltransferase / analysis*


  • gamma-Glutamyltransferase
  • Cathepsins
  • Aminopeptidases
  • Dipeptidyl-Peptidases and Tripeptidyl-Peptidases
  • Cathepsin C
  • dipeptidyl peptidase II
  • Dipeptidyl Peptidase 4
  • Cathepsin B