Impact of a Soccer Game on Cardiac Biomarkers in Adolescent Players

Pediatr Exerc Sci. 2018 Feb 1;30(1):90-95. doi: 10.1123/pes.2017-0060. Epub 2017 Sep 22.


Purpose: Biochemical markers such as cardiac troponin I (cTnI) and N-terminal pro B-type natriuretic peptide (NT-proBNP) have become indispensable tools for the diagnosis of myocardial injury, providing highly sensitive and specific information about cardiac cell damage and wall stress. The purpose of the present research was to examine the response of cardiac biomarkers to a soccer game in adolescent male soccer players.

Methods: Twenty-two trained adolescent male soccer players (14-16 y) were selected in a purposive manner. Blood samples were taken before, immediately after, and 2 and 24 hours after the game for the determination of cTnI and NT-proBNP.

Results: Serum concentration of cTnI and NT-proBNP increased immediately and 2 hours after the soccer game (P < .001). After 24 hours, the levels of cTnI dropped but remained above baseline (P = .002), whereas serum NT-proBNP levels returned to baseline. At no time point did any of the values exceed the upper reference value.

Conclusions: This is the first study to investigate the acute responses of cardiac biomarkers to a soccer game in adolescent male players. The postgame elevation of cardiac biomarkers and their rapid recovery are indicative of a physiological rather than a pathological response.

Keywords: Myocardial injury; NT-proBNP; cTnI.

MeSH terms

  • Adolescent
  • Biomarkers / blood
  • Humans
  • Male
  • Natriuretic Peptide, Brain / blood*
  • Peptide Fragments / blood*
  • Soccer / physiology*
  • Troponin I / blood*


  • Biomarkers
  • Peptide Fragments
  • Troponin I
  • pro-brain natriuretic peptide (1-76)
  • Natriuretic Peptide, Brain