The use of fibrinogen concentrate for the management of trauma-related bleeding: a systematic review and meta-analysis

Blood Transfus. 2017 Jul;15(4):318-324. doi: 10.2450/2017.0094-17.

Abstract

Haemorrhage following injury is associated with significant morbidity and mortality. The role of fibrinogen concentrate in trauma-induced coagulopathy has been the object of intense research in the last 10 years and has been systematically analysed in this review. A systematic search of the literature identified six retrospective studies and one prospective one, involving 1,650 trauma patients. There were no randomised trials. Meta-analysis showed that fibrinogen concentrate has no effect on overall mortality (risk ratio: 1.07, 95% confidence interval: 0.83-1.38). Although the meta-analytic pooling of the current literature evidence suggests no beneficial effect of fibrinogen concentrate in the setting of severe trauma, the quality of data retrieved was poor and the final results of ongoing randomised trials will help to further elucidate the role of fibrinogen concentrate in traumatic bleeding.

Publication types

  • Meta-Analysis
  • Review
  • Systematic Review

MeSH terms

  • Disease-Free Survival
  • Female
  • Fibrinogen / therapeutic use*
  • Hemorrhage / drug therapy*
  • Hemorrhage / mortality*
  • Humans
  • Male
  • Survival Rate
  • Trauma Severity Indices
  • Wounds and Injuries / drug therapy*
  • Wounds and Injuries / mortality*

Substances

  • Fibrinogen