The Cardiovascular Effects of Cocaine

J Am Coll Cardiol. 2017 Jul 4;70(1):101-113. doi: 10.1016/j.jacc.2017.05.014.


Cocaine is the leading cause for drug-abuse-related visits to emergency departments, most of which are due to cardiovascular complaints. Through its diverse pathophysiological mechanisms, cocaine exerts various adverse effects on the cardiovascular system, many times with grave results. Described here are the varied cardiovascular effects of cocaine, areas of controversy, and therapeutic options.

Keywords: acute myocardial infarction; beta-blockers; cardiomyopathy; cocaine cardiotoxicity; drug addiction.

Publication types

  • Review

MeSH terms

  • Cardiovascular Diseases / chemically induced*
  • Cardiovascular Diseases / epidemiology
  • Cocaine / adverse effects*
  • Global Health
  • Humans
  • Morbidity
  • Substance-Related Disorders / complications*


  • Cocaine