Molecular and phenotypic biomarkers of aging

F1000Res. 2017 Jun 9:6:860. doi: 10.12688/f1000research.10692.1. eCollection 2017.


Individuals of the same age may not age at the same rate. Quantitative biomarkers of aging are valuable tools to measure physiological age, assess the extent of 'healthy aging', and potentially predict health span and life span for an individual. Given the complex nature of the aging process, the biomarkers of aging are multilayered and multifaceted. Here, we review the phenotypic and molecular biomarkers of aging. Identifying and using biomarkers of aging to improve human health, prevent age-associated diseases, and extend healthy life span are now facilitated by the fast-growing capacity of multilevel cross-sectional and longitudinal data acquisition, storage, and analysis, particularly for data related to general human populations. Combined with artificial intelligence and machine learning techniques, reliable panels of biomarkers of aging will have tremendous potential to improve human health in aging societies.

Keywords: age-associated diseases; aging process; molecular; phenotypic; physiological age.

Publication types

  • Review

Grants and funding

This work was supported by grants from the China Ministry of Science and Technology (2015CB964803 and 2016YFE0108700) and the National Natural Science Foundation of China (91329302, 31210103916, and 91519330) and the Chinese Academy of Sciences XDB19020301 and XDA01010303 to J-DJH.