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. 2018 Feb;41(1):163-165.
doi: 10.1111/jvp.12430. Epub 2017 Jun 29.

The Influence of Rapid Growth on Sodium Salicylate Pharmacokinetics in Male Turkeys

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The Influence of Rapid Growth on Sodium Salicylate Pharmacokinetics in Male Turkeys

B Poźniak et al. J Vet Pharmacol Ther. .

Abstract

The aim of this study was to assess the influence of growth on the pharmacokinetics of sodium salicylate (SS) in male turkeys. SS was administered intravenously at a dose of 50 mg/kg. Plasma drug concentrations were assessed by high-performance liquid chromatography, and pharmacokinetic parameters were calculated by noncompartmental analysis. As the age increased from 6 to 13 weeks (body weight increase from 2.35 to 9.43 kg), median body clearance decreased from 1.34 to 0.87 ml/min/kg. This caused a significant increase in the median mean residence time from 3.42 to 4.44 hr. Elimination phase proved to be biphasic and two elimination half-lives (T1/2el ) were distinguished. Whereas T1/2el1 was found to increase with age by 128%, T1/2el2 represented a later but faster and less age-dependent phase of elimination (increase by 56% in the respective groups). Volume of distribution decreased with age. These effects may lead to different therapeutic response to SS in turkeys of different age and body weights.

Keywords: age; growth; pharmacokinetics; sodium salicylate; turkeys.

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