Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Dec;17(23-24).
doi: 10.1002/pmic.201600431. Epub 2017 Oct 12.

Autotransporter Adhesins in Escherichia Coli Pathogenesis


Autotransporter Adhesins in Escherichia Coli Pathogenesis

Julieanne L Vo et al. Proteomics. .


Most bacteria produce adhesion molecules to facilitate the interaction with host cells and establish successful infections. An important group of bacterial adhesins belong to the autotransporter (AT) superfamily, the largest group of secreted and outer membrane proteins in Gram-negative bacteria. AT adhesins possess diverse functions that facilitate bacterial colonisation, survival and persistence, and as such are often associated with increased bacterial fitness and pathogenic potential. In this review, we will describe AIDA-I type AT adhesins, which comprise the biggest and most diverse group in the AT family. We will focus on Escherichia coli proteins and define general aspects of their biogenesis, distribution, structural properties and key roles in infection.

Keywords: autotransporter adhesins; bacterial aggregation; bacterial pathogenesis; biofilm formation factor; type V secretion system.

Similar articles

See all similar articles

Cited by 8 articles

See all "Cited by" articles

MeSH terms


LinkOut - more resources