Morning glory disc anomaly with an ipsilateral enlargement of the optic nerve pathway

Eur J Paediatr Neurol. 2017 Sep;21(5):787-791. doi: 10.1016/j.ejpn.2017.04.1334. Epub 2017 May 19.


Purpose: To report three patients with an unilateral morning glory disc anomaly in association with an ipsilateral mild thickening of the optic nerve.

Methods: Three children with a morning glory disc anomaly underwent a magnetic resonance imaging (MRI) of the brain. Ophthalmological, genetic and MRI findings at follow-up are reported. A literature search on the association of morning glory anomaly in association with optic nerve glioma is reported.1 RESULTS: Three children with an unilateral morning glory anomaly and ipsilateral poor visual acuity were found to have an ipsilateral mild optic nerve enlargement on brain MRI. At serial MRI scanning, there was no progression of this finding.

Conclusions: The morning glory disc anomaly is a rare congenital malformation of the optic disc. It can be associated with central nervous system abnormalities. The association with an optic nerve glioma has been described once before.1 Our three cases confirm the possible association between a morning glory disc anomaly and an ipsilateral optic nerve enlargement. Serial MRI showed no growth at follow-up. The awareness of this association by the ophthalmologists is important.

Keywords: Congenital eye disorders; Congenital malformation optic disc; Morning glory optic disc; Optic nerve glioma; Optic nerve thickening.

Publication types

  • Case Reports

MeSH terms

  • Brain / diagnostic imaging*
  • Child, Preschool
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Optic Disk / abnormalities*
  • Optic Nerve / abnormalities*
  • Vision Disorders / diagnostic imaging
  • Vision Disorders / etiology*