Diagnosis of lower gastrointestinal bleeding by multi-slice CT angiography: A meta-analysis

Bosheng He; Jushun Yang; Jing Xiao; Jinhua Gu; Feixiang Chen; Lin Wang; Chengjin Zhao; Junbo Qian; Shenchu Gong

doi:10.1016/j.ejrad.2017.05.020

Diagnosis of lower gastrointestinal bleeding by multi-slice CT angiography: A meta-analysis

Eur J Radiol. 2017 Aug:93:40-45. doi: 10.1016/j.ejrad.2017.05.020. Epub 2017 May 18.

Authors

Bosheng He¹, Jushun Yang¹, Jing Xiao², Jinhua Gu³, Feixiang Chen¹, Lin Wang¹, Chengjin Zhao⁴, Junbo Qian⁴, Shenchu Gong⁵

Affiliations

¹ Department of Radiology, the Second Affiliated Hospital of Nantong University, Jiangsu 226001, China.
² Department of Epidemiology and Medical Statistics, School of Public Health, Nantong University, Nantong, Jiangsu 226019, China.
³ Department of Pathophysiology, Nantong University Medical School, Nantong, Jiangsu 226001, China.
⁴ Department of Gastroenterology, the Second Affiliated Hospital of Nantong University, Jiangsu 226001, China.
⁵ Department of Radiology, the Second Affiliated Hospital of Nantong University, Jiangsu 226001, China. Electronic address: gongshenchu78@hotmail.com.

PMID: 28668429
DOI: 10.1016/j.ejrad.2017.05.020

Abstract

Purpose: To estimate the diagnostic value of multi-slice spiral CT angiography (CTA) in lower gastrointestinal bleeding by a meta-analysis.

Methods: The relevant clinical studies on the diagnostic value of CTA were searched on PubMed, Embase and other electronic documents databases with the deadline of 2016 September. Language was limited to English. A diagnostic meta-analysis was performed by using Meta-DiSc software. The effect sizes included sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), and diagnostic odds ratio (DOR) and 95% confidence interval (CI). The Cochran-Q test and I² statistic based on χ² test were used for estimation of the heterogeneity. Meta-regression was performed to explore the source of heterogeneity. SROC curve was established.

Results: A total of 14 articles including 549 patients with lower gastrointestinal bleeding were enrolled in the meta-analysis. The combined PLR, NLR and DOR were respectively 8.149, 0.158 and 56.213. There were significant heterogeneities in all estimations but we could not find the sources by meta-regression based on study design, study location, CT slices and sample size. The AUC and Q index under the fixed effect model was respectively 0.9463 and 0.8856.

Conclusions: The multi-slice CTA has high diagnostic value for lower gastrointestinal bleeding.

Keywords: Angiography; Diagnosis; Hemorrhage; Lower gastrointestinal tract; Meta-analysis; Multi-slice computed tomography.

Publication types

Meta-Analysis

MeSH terms

Computed Tomography Angiography / methods*
Gastrointestinal Hemorrhage / diagnostic imaging*
Humans
Lower Gastrointestinal Tract / diagnostic imaging*
Sensitivity and Specificity