Abstract
In this study, we assessed the selective effect of colistin administered orally to healthy weaned piglets harbouring an intestinal mcr-1-positive Escherichia coli strain. Maximum recommended dose and a higher dose often used in European pig farms were given by gavage. No selection of the mcr-1-positive strain was observed in our controlled conditions, irrespective of the dose. Further investigations in real farming conditions seem necessary.
Keywords:
Colistin; Escherichia coli; Piglets; Selection; mcr-1.
Copyright © 2017 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.
MeSH terms
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Administration, Oral
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Animals
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Anti-Bacterial Agents / administration & dosage
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Anti-Bacterial Agents / pharmacology*
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Colistin / administration & dosage
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Colistin / pharmacology*
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Drug Resistance, Bacterial / genetics
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Escherichia coli / drug effects*
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Escherichia coli / genetics*
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Escherichia coli Infections / drug therapy
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Escherichia coli Infections / microbiology
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Escherichia coli Proteins / genetics*
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Farms
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Feces / chemistry
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Feces / microbiology
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Intestines / microbiology
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Rifampin / pharmacology
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Swine
Substances
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Anti-Bacterial Agents
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Escherichia coli Proteins
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MCR-1 protein, E coli
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Rifampin
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Colistin