Topical Review: MACI as an Emerging Technology for the Treatment of Talar Osteochondral Lesions

Foot Ankle Int. 2017 Sep;38(9):1045-1048. doi: 10.1177/1071100717711482. Epub 2017 Jul 1.


Matrix-induced autologous chondrocyte implantation (MACI) is a viable procedure that can be used as both a primary or revision cartilage regenerative procedure in high-functioning individuals without tibiotalar arthritis. Both short-term and midterm follow-up results demonstrate clinical, radiographic, and functional improvements with high rates of return to full activities. Cost remains a chief concern with the use of this technique, but theoretical improvements in the durability of repair with type II cartilage replacement may offer long-term benefits.

Level of evidence: Level V, expert opinion.

Keywords: arthritis; sports.

MeSH terms

  • Arthroscopy / methods
  • Cartilage, Articular / physiopathology*
  • Chondrocytes / chemistry
  • Chondrocytes / physiology*
  • Humans
  • Talus
  • Transplantation, Autologous / methods*
  • Treatment Outcome