Catalyst-free N-formylation of amines using BH3NH3 and CO2 under mild conditions

Tian-Xiang Zhao; Gao-Wen Zhai; Jian Liang; Ping Li; Xing-Bang Hu; You-Ting Wu

doi:10.1039/c7cc03860g

Catalyst-free N-formylation of amines using BH₃NH₃ and CO₂ under mild conditions

Chem Commun (Camb). 2017 Jul 13;53(57):8046-8049. doi: 10.1039/c7cc03860g.

Authors

Tian-Xiang Zhao¹, Gao-Wen Zhai, Jian Liang, Ping Li, Xing-Bang Hu, You-Ting Wu

Affiliation

¹ School of Chemistry and Chemical Engineering, Separation Engineering Research Center, Nanjing University, Nanjing 210093, P. R. China. huxb@nju.edu.cn ytwu@nju.edu.cn.

PMID: 28671215
DOI: 10.1039/c7cc03860g

Abstract

The catalyst-free N-formylation of amines using CO₂ as the C₁ source and BH₃NH₃ as the reductant has been developed for the first time. The corresponding formylated products of both primary and secondary amines are obtained in good to excellent yields (up to 96% of isolated yield) under mild conditions.