Antibacterial Activities of Pyrenylated Coumarins from the Roots of Prangos hulusii

Molecules. 2017 Jul 1;22(7):1098. doi: 10.3390/molecules22071098.


The dichloromethane extract of the roots of Prangos hulusii, a recently described endemic species from Turkey, has yielded nine known and one new prenylated coumarins. The structures were elucidated by spectroscopic methods and direct comparison with the reference compounds where available. The root extract and its prenylated coumarins exhibit antimicrobial activity against nine standard and six clinically isolated strains at a concentration between 5 and 125 µg/mL. In particular, the new coumarin, 4'-senecioiloxyosthol (1), displayed 5 µg/mL MIC (Minimum Inhibitory Concentration) value against Bacillus subtilis ATCC 9372, murraol (4) and auraptenol (5) showed 63 µg/mL MIC value against Klebsiella pneumoniae ATCC 4352 and Bacillus subtilis ATCC 9372, and isoimperatorin (9) exhibited 16 µg/mL MIC value.

Keywords: Prangos hulusii; antibacterial activity; pyrenylated coumarins.

MeSH terms

  • Anti-Bacterial Agents / chemistry*
  • Anti-Bacterial Agents / pharmacology
  • Bacillus subtilis / drug effects
  • Coumarins / chemistry
  • Coumarins / pharmacology
  • Gram-Negative Bacteria / drug effects*
  • Klebsiella pneumoniae / drug effects
  • Methylene Chloride / chemistry
  • Methylene Chloride / pharmacology
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Plant Extracts / chemistry*
  • Plant Extracts / pharmacology
  • Plant Roots / chemistry*


  • Anti-Bacterial Agents
  • Coumarins
  • Plant Extracts
  • Methylene Chloride