The double-edged sword of evolution

Elife. 2017 Jul 3;6:e29056. doi: 10.7554/eLife.29056.


Two gene variants provide different levels of protection against sleeping sickness, but this comes with an increased risk of developing chronic kidney disease.

Keywords: Human African Trypanosomiasis; Trypanosoma brucei; Trypanosoma brucei gambiense; Trypanosoma brucei rhodesiense; chronic kidney disease; evolutionary biology; genomics; human; infectious disease; microbiology; sleeping sickness.

Publication types

  • Comment

MeSH terms

  • Animals
  • Apolipoprotein L1
  • Trypanosoma brucei gambiense
  • Trypanosoma brucei rhodesiense
  • Trypanosomiasis, African*


  • Apolipoprotein L1