Circulating CD89-IgA complex does not predict deterioration of kidney function in Korean patients with IgA nephropathy

Clin Chem Lab Med. 2017 Nov 27;56(1):75-85. doi: 10.1515/cclm-2017-0090.


Background: Soluble CD89 (sCD89)-IgA complex plays a key role in the pathogenesis of IgA nephropathy (IgAN). However, there is a lack of evidence supporting this complex as a good biomarker for disease progression. This study aimed to evaluate the usefulness of sCD89-IgA complex for risk stratification of IgAN.

Methods: A total of 326 patients with biopsy-proven IgAN were included. sCD89-IgA complex was measured by sandwich-enzyme-linked immunosorbent assay. The study endpoints were a 30% decline in estimated glomerular filtration rate (eGFR).

Results: sCD89-IgA complex levels were inversely and weakly associated with eGFR at the time of biopsy (r=-0.12, p=0.03). However, the significance between the two factors was lost in the multivariate linear regression after adjustment of clinical factors (β=0.35, p=0.75). In a multivariate Cox model, the highest (hazard ratio [HR], 0.75; 95% confidence interval [CI], 0.35-1.61; p=0.45) and middle (HR, 0.93; 95% CI, 0.46-1.89; p=0.84) tertiles of sCD89-IgA complex levels were not associated with an increased risk of developing a 30% decrease in eGFR. Furthermore, the decline rates in eGFR did not differ between groups and C-statistics revealed that the sCD89-IgA complex were not superior to clinical factors in predicting disease progression.

Conclusions: This study found no association between sCD89-IgA complex levels and disease progression in IgAN. Although sCD89 can contribute to the formation of immune complexes, our findings suggest that the sCD89-IgA level is not a good predictor of adverse outcomes and has limited clinical utility as a biomarker for risk stratification in IgAN.

Keywords: CD89; IgA nephropathy; estimated glomerular filtration rate (eGFR).

MeSH terms

  • Adult
  • Antigens, CD / blood*
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Glomerular Filtration Rate
  • Glomerulonephritis, IGA / blood*
  • Glomerulonephritis, IGA / pathology
  • Humans
  • Immunoglobulin A / blood*
  • Kidney Function Tests
  • Male
  • Receptors, Fc / blood*
  • Republic of Korea
  • Risk Factors


  • Antigens, CD
  • Fc(alpha) receptor
  • Immunoglobulin A
  • Receptors, Fc