Cardiovascular and Metabolic Diseases Comorbid With Psoriasis: Beyond the Skin

Intern Med. 2017;56(13):1613-1619. doi: 10.2169/internalmedicine.56.8209. Epub 2017 Jul 1.


A close association of systemic inflammation with cardiovascular diseases and metabolic syndrome is recently a popular topic in medicine. Psoriasis is a chronic inflammatory skin disease with a prevalence of approximately 0.1-0.5% in Asians. It is characterized by widespread scaly erythematous macules that cause significant physical and psychological burdens for the affected individuals. The accelerated inflammation driven by the TNF-α/IL-23/IL-17A axis is now known to be the major mechanism in the development of psoriasis. Psoriasis is not a mere skin disease; it is significantly associated with cardiovascular diseases and metabolic syndrome, which suggests that the chronic skin inflammation extends the systemic inflammation beyond the skin. In this article, we review the epidemiological and pathological aspects of psoriasis and its comorbidities.

Keywords: cardiovascular disease; interleukin 17; interleukin 23; metabolic syndrome; psoriasis; tumor necrosis factor α.

Publication types

  • Review

MeSH terms

  • Cardiovascular Diseases / epidemiology*
  • Cardiovascular Diseases / physiopathology
  • Chronic Disease
  • Humans
  • Inflammation / epidemiology*
  • Inflammation / physiopathology*
  • Interleukin-17 / metabolism
  • Metabolic Syndrome / epidemiology*
  • Metabolic Syndrome / physiopathology
  • Psoriasis / epidemiology*
  • Psoriasis / physiopathology*
  • Tumor Necrosis Factor-alpha / metabolism


  • Interleukin-17
  • Tumor Necrosis Factor-alpha