A compendium of ERK targets

FEBS Lett. 2017 Sep;591(17):2607-2615. doi: 10.1002/1873-3468.12740. Epub 2017 Jul 25.


The RAF-MEK-ERK cascade is one of the most studied signaling pathways as it controls many vital cellular programs. There has been an immense amount of effort to determine ERK target proteins involved in regulating these programs. Classical biochemical and genetic approaches have elicited hundreds of direct ERK substrates, and with the advent of phospho-proteomic technologies, numerous studies have expanded the number of ERK target proteins. Here, we compile a comprehensive ERK target phospho-site archive, in which we gathered information from various research studies, and we provide this archive as an online database to form a searchable compendium of ERK targets.

Keywords: ERK targets; MAP kinase signaling; RAF-MEK-ERK; phosphorylation.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Extracellular Signal-Regulated MAP Kinases / metabolism*
  • Humans
  • MAP Kinase Signaling System
  • Proteomics / methods*


  • Extracellular Signal-Regulated MAP Kinases