Combination alprazolam-neuroleptic treatment of the positive and negative symptoms of schizophrenia

O M Wolkowitz; D Pickar; A R Doran; A Breier; J Tarell; S M Paul

doi:10.1176/ajp.143.1.85

Combination alprazolam-neuroleptic treatment of the positive and negative symptoms of schizophrenia

Am J Psychiatry. 1986 Jan;143(1):85-7. doi: 10.1176/ajp.143.1.85.

Authors

O M Wolkowitz, D Pickar, A R Doran, A Breier, J Tarell, S M Paul

PMID: 2867690
DOI: 10.1176/ajp.143.1.85

Abstract

Alprazolam, when added under double-blind conditions to a stable neuroleptic regimen in two patients with schizophrenia, resulted in clinically apparent improvement in positive and negative schizophrenic symptoms. Both patients showed significant worsening of symptoms following reduction or discontinuation of alprazolam.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Alprazolam
Anti-Anxiety Agents / therapeutic use*
Antipsychotic Agents / therapeutic use
Benzodiazepines / therapeutic use*
Double-Blind Method
Drug Therapy, Combination
Fluphenazine / therapeutic use*
Humans
Male
Psychiatric Status Rating Scales
Schizophrenia / drug therapy*
Schizophrenic Psychology

Substances

Anti-Anxiety Agents
Antipsychotic Agents
Benzodiazepines
Fluphenazine
Alprazolam