Modeling human disease in rodents by CRISPR/Cas9 genome editing

Mamm Genome. 2017 Aug;28(7-8):291-301. doi: 10.1007/s00335-017-9703-x. Epub 2017 Jul 4.


Modeling human disease has proven to be a challenge for the scientific community. For years, generating an animal model was complicated and restricted to very few species. With the rise of CRISPR/Cas9, it is now possible to generate more or less any animal model. In this review, we will show how this technology is and will change our way to obtain relevant disease animal models and how it should impact human health.

Publication types

  • Review

MeSH terms

  • Animals
  • Animals, Genetically Modified
  • CRISPR-Cas Systems*
  • Disease Models, Animal
  • Gene Editing*
  • Genetic Association Studies / methods*
  • Genetic Predisposition to Disease*
  • Genetic Therapy / methods
  • Genetic Variation
  • Genomics / methods
  • Humans
  • Mice
  • Models, Biological*
  • Multifactorial Inheritance
  • Open Reading Frames
  • Precision Medicine
  • RNA, Untranslated
  • Regulatory Sequences, Ribonucleic Acid


  • RNA, Untranslated
  • Regulatory Sequences, Ribonucleic Acid