Intercorrelations of morphology with hemodynamics in intracranial aneurysms in computational fluid dynamics

Neurosciences (Riyadh). 2017 Jul;22(3):205-212. doi: 10.17712/nsj.2017.3.20160452.


Objective: To measure morphological indices and wall shear stress (WSS) of aneurysms and parent artery surface in order to explore the relationship of morphological characteristics and WSS.

Methods: Data from 47 events of consecutive cerebral saccular aneurysms from 39 patients which were referred to the interventional Neuroradiology service of the Shaoxing People`s Hospital, Shaoxing, China between 2014 April and 2015 August. Wall shear stress and wall pressure (WP) of the pre-aneurysm, aneurysm and near vessel (<1.0 cm) surface were obtained. Correlation analysis was carried between morphological parameters and WSS and its ratio. WSS, WP, intra-aneurysmal flow pattern, and location of aneurysms were analyzed.

Results: Impaction zone from inflow jet was located in the distal neck part of aneurysm with high WSS in 36 aneurysms (76.6%). There were significant differences in WSS between pre-aneurysm surface and near vessel (p<0.001), aneurysm (p<0.001), aneurysm and near vessel (p<0.001). Significant correlations were found between aneurysm WSS and aspect ratio (r=-0.296), aneurysm-artery WSS ratio and size ratio (r=-0.322), aspect ratio (r=-0.416).

Conclusion: Uneven WSS distributes in the various part of the pre-aneurysm vessel. The impaction zone from inflow jet is located in the distal neck of aneurysm. Aspect and size ratios can effect aneurysm WSS.

MeSH terms

  • Brain / blood supply*
  • Cerebral Angiography / methods
  • Hemodynamics / physiology*
  • Humans
  • Hydrodynamics*
  • Imaging, Three-Dimensional
  • Intracranial Aneurysm / physiopathology*
  • Stress, Mechanical*