Genetic approaches to retinal research in zebrafish

J Neurogenet. 2017 Sep;31(3):70-87. doi: 10.1080/01677063.2017.1343316. Epub 2017 Jul 5.


The zebrafish (Danio rerio) possesses a vertebrate-type retina that is extraordinarily conserved in evolution. This well-organized and anatomically easily accessible part of the central nervous system has been widely investigated in zebrafish, promoting general understanding of retinal development, morphology, function and associated diseases. Over the recent years, genome and protein engineering as well as imaging techniques have experienced revolutionary advances and innovations, creating new possibilities and methods to study zebrafish development and function. In this review, we focus on some of these emerging technologies and how they may impact retinal research in the future. We place an emphasis on genetic techniques, such as transgenic approaches and the revolutionizing new possibilities in genome editing.

Keywords: Retina; forward genetics; reverse genetics; transgenesis; zebrafish.

Publication types

  • Review

MeSH terms

  • Animals
  • Animals, Genetically Modified*
  • Genetic Techniques*
  • Retina / physiology*
  • Zebrafish / anatomy & histology*