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. 2018 Aug;20(8):781-792.
doi: 10.1080/10286020.2017.1346629. Epub 2017 Jul 5.

Berberine Hydrochloride Counteracts Enhanced IL-8 Expression Induced by SN 38 in AGS Cells

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Berberine Hydrochloride Counteracts Enhanced IL-8 Expression Induced by SN 38 in AGS Cells

Jin Chen et al. J Asian Nat Prod Res. .

Abstract

IL-8 over-expression could enhance cancer metastasis. In present study, berberine hydrochloride (BER) triggered proliferative inhibition and G2/M arrest in AGS cells, down-regulated protein expression of cyclin B1, Bcl-2, up-regulated expression of p21, p53 and cleaved caspase 3, but showed no effect on protein expression of CHOP, Bip, and caspase 4. BER could down-regulate the enhanced IL-8 expression through down-regulating ERK1/2 and p38 MAPK over-activation induced by SN 38. The increased IL-8 mediated adhesive ability of AGS cells to HUVECs induced by SN 38, could be reduced by BER. Thus, BER could reduce the side-effect of SN 38 in clinic.

Keywords: AGS cells; IL-8; SN 38; adhesion; berberine hydrochloride.

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