Zika virus infection: report of the first imported cases in a Paris travel centre

Aurélien Sokal; Eric D'Ortenzio; Nadira Houhou-Fidouh; Ségolène Brichler; Justine Dorchies; Ornella Cabras; Isabelle Leparc-Goffart; Yazdan Yazdanpanah; Sophie Matheron

doi:10.1093/jtm/taw066

Zika virus infection: report of the first imported cases in a Paris travel centre

J Travel Med. 2016 Jul 1;24(1). doi: 10.1093/jtm/taw066.

Authors

Aurélien Sokal¹, Eric D'Ortenzio^{1

2}, Nadira Houhou-Fidouh³, Ségolène Brichler⁴, Justine Dorchies¹, Ornella Cabras¹, Isabelle Leparc-Goffart⁵, Yazdan Yazdanpanah^{1

2

6}, Sophie Matheron^{1

2

6}

Affiliations

¹ Service des Maladies Infectieuses et Tropicales, AP-HP, Hôpital Bichat, Hôpitaux Paris Nord Val de Seine, Paris, France.
² INSERM, Infections, Antimicrobiens, Modélisation, Evolution (IAME), UMR 1137, Paris, France.
³ Service de Virologie, AP-HP, Hôpital Bichat, Hôpitaux Paris Nord Val de Seine, Paris, France.
⁴ Service de Virologie, AP-HP, Hôpital Avicenne, Hôpitaux Universitaires Paris Seine-Saint-Denis, Bobigny, France.
⁵ Centre national de Reference des Arbovirus, Institut de Recherche Biomédicale des Armées, Marseille, France.
⁶ Université Paris Diderot, Sorbonne Paris Cité, France 7, Denis Diderot, Paris, France.

PMID: 28679155
DOI: 10.1093/jtm/taw066

Abstract

We describe characteristics of 17 patients with a Zika virus (ZIKV) infection seen in a Travel Center in Paris during the 4 months following the WHO alert on ZIKV. Sixteen were imported cases, including 13 from the Caribbean. One was a women living in Paris infected through sexual transmission. One case was a pregnant woman. All cases were symptomatic with fever, fatigue and cutaneous rash in 15/17, 13/17, and 16/17, respectively. Leucopenia was observed in 6/17, thrombopenia in 2/17. Diagnosis was confirmed by ZIKV RT-PCR (plasma: 12/17; urine 15/17) or detection of ZIKV IgM (2/17). Two patients were hospitalized but all evolved well.

Keywords: Zika virus; arbovirus; importation cases.

MeSH terms

Caribbean Region / epidemiology
Exanthema
Fatigue
Female
Fever
Humans
Paris
Pregnancy
Thrombocytopenia / etiology
Travel*
Zika Virus
Zika Virus Infection / diagnosis*
Zika Virus Infection / physiopathology*
Zika Virus Infection / transmission