Risk Factors of Mortality from All Asbestos-Related Diseases: A Competing Risk Analysis

Can Respir J. 2017;2017:9015914. doi: 10.1155/2017/9015914. Epub 2017 Jun 7.

Abstract

Background: The mortality from all malignant and nonmalignant asbestos-related diseases remains unknown. The authors assessed the incidence and risk factors for all asbestos-related deaths.

Methods: The sample included 544 patients from an asbestos-exposed community in the area of Barcelona (Spain), between Jan 1, 1970, and Dec 31, 2006. Competing risk regression through a subdistribution hazard analysis was used to estimate risk factors for the outcomes.

Results: Asbestos-related deaths were observed in 167 (30.7%) patients and 57.5% of these deaths were caused by some type of mesothelioma. The incidence rate after diagnosis was 3,600 per 100,000 person-years. In 7.5% of patients death was non-asbestos-related, while pleural and peritoneal mesothelioma were identified in 87 (16.0%) and 18 (3.3%) patients, respectively.

Conclusions: Age, sex, household exposure, cumulative nonmalignant asbestos-related disease, and single malignant pathology were identified as risk factors for asbestos-related death. These findings suggest the need to develop a preventive approach to the community and to improve the clinical follow-up process of these patients.

MeSH terms

  • Age Factors
  • Aged
  • Aged, 80 and over
  • Asbestos / adverse effects*
  • Asbestosis / mortality*
  • Cohort Studies
  • Environmental Exposure / statistics & numerical data
  • Female
  • Humans
  • Incidence
  • Lung Neoplasms / mortality*
  • Male
  • Mesothelioma / mortality*
  • Middle Aged
  • Mortality
  • Occupational Diseases / mortality
  • Occupational Exposure / statistics & numerical data*
  • Peritoneal Neoplasms / mortality*
  • Pleural Neoplasms / mortality*
  • Proportional Hazards Models
  • Retrospective Studies
  • Risk Assessment
  • Risk Factors
  • Sex Factors
  • Smoking / epidemiology
  • Spain / epidemiology

Substances

  • Asbestos