Bone Marrow Necrosis in Newly Diagnosed Acute Leukemia: Two Case Reports and Review of the Literature

Adrien Quintela; Pierre Sujobert; Isabelle Tigaud; Sandrine Hayette; Martine Ffrench; Gilles Salles; Xavier Thomas; Adriana Plesa

doi:10.1007/s40487-017-0041-7

Bone Marrow Necrosis in Newly Diagnosed Acute Leukemia: Two Case Reports and Review of the Literature

Oncol Ther. 2017;5(1):111-118. doi: 10.1007/s40487-017-0041-7. Epub 2017 Feb 9.

Authors

Adrien Quintela¹, Pierre Sujobert², Isabelle Tigaud³, Sandrine Hayette², Martine Ffrench¹, Gilles Salles¹, Xavier Thomas¹, Adriana Plesa⁴

Affiliations

¹ Department of Hematology, CHU Lyon-Sud Hospital, Hospices Civils de Lyon, Lyon, France.
² Laboratory of Molecular Biology, CHU Lyon-Sud Hospital, Hospices Civils de Lyon, Lyon, France.
³ Laboratory of Cytogenetics, CHU Lyon-Sud Hospital, Hospices Civils de Lyon, Lyon, France.
⁴ Laboratory of Hematology and Flow Cytometry, CHU Lyon-Sud Hospital, Hospices Civils de Lyon, Lyon, France.

Abstract

Bone marrow necrosis (BMN) in acute leukemia is a rare histopathological entity at the time of initial diagnosis. However, it represents an important diagnostic and prognostic challenge. Two cases of BMN are reported: a 44-year-old patient with B cell precursor (BCP) acute lymphoblastic leukemia (ALL) and a 27-year-old man with FAB-M5 acute myeloid leukemia (AML) who both presented with bone marrow failure and extensive necrosis. From these clinical cases, we conducted a brief review of the literature.

Keywords: Acute leukemia; Bone marrow necrosis; Chemotherapy; Prognosis.