Optimal Therapy of Advanced Stage Mesothelioma

Curr Treat Options Oncol. 2017 Aug;18(8):48. doi: 10.1007/s11864-017-0488-7.

Abstract

The optimal treatment of patients with advanced malignant pleural mesothelioma (MPM) has not yet been discovered. With the aid of an increased insight in the molecular pathways and the development of combinations of Immuno-Oncology (IO), drugs new therapies are available. The personalization of treatment by cell cultures and pathway analysis attracts more attention nowadays. It is conceivable that in the near future the treatment of patients with MPM will consist of a combination of IO drugs or specific pathway inhibitors.

Keywords: Immuno-oncology drugs; Malignant pleural mesothelioma; Pathway inhibitors; Therapy.

Publication types

  • Review

MeSH terms

  • Animals
  • Antineoplastic Combined Chemotherapy Protocols / adverse effects
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Clinical Trials as Topic
  • Disease Management
  • Humans
  • Immunotherapy
  • Lung Neoplasms / mortality
  • Lung Neoplasms / pathology
  • Lung Neoplasms / therapy
  • Mesothelioma / etiology
  • Mesothelioma / mortality
  • Mesothelioma / pathology*
  • Mesothelioma / therapy*
  • Mesothelioma, Malignant
  • Molecular Targeted Therapy
  • Neoplasm Staging
  • Pleural Neoplasms / mortality
  • Pleural Neoplasms / pathology
  • Pleural Neoplasms / therapy
  • Prognosis
  • Treatment Outcome